Fifty-five individuals were initially contacted to participate in the study. Stimulation motor function skilled motor practice transcallosal inhibition transcranial magnetic stimulation.ĬONSORT Participant flow chart. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. In addition, we observed an association between STT performance change and paretic WMFT-rate change in the M1c stimulation group only. TCI was reduced bi-directionally following the intervention, regardless of stimulation group. Assessment of bilateral corticospinal, intracortical excitability and TCI were secondary outcomes.ĬTBS over sensorimotor cortex did not improve STT performance and paretic WMFT-rate beyond sham cTBS. Changes in STT performance and Wolf Motor Function Test (WMFT) were assessed as primary outcomes.
Stim cs 1.6 serial#
We considered the differential effects of stimulation over two different brain regions: contralesional M1 (M1c) or contralesional primary somatosensory cortex (S1c).ģ7 individuals with chronic stroke participated in five sessions of cTBS and paretic arm skilled practice of a serial targeting task (STT) participants received either cTBS over M1c or S1c or sham before STT practice. Here, we investigated the effects of pairing cTBS with skilled practice on motor learning and arm function. Variable effects of cTBS could stem from failure to pair stimulation with skilled motor practice or a focus of applying cTBS over M1. However, contralesional cTBS shows inconsistent effects after stroke. Continuous theta burst stimulation (cTBS) can decrease primary motor cortex (M1) excitability and TCI. In individuals with chronic stroke, impairment of the paretic arm may be exacerbated by increased contralesional transcallosal inhibition (TCI).
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